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Review
Premedication for less invasive surfactant administration: a narrative review
  1. Claire A Murphy1,
  2. Kevin CW Goss2,
  3. Rebeccah Slater3,
  4. Shalini Ojha4,5,
  5. Peter A Dargaville6,7,
  6. Chris Gale1,8
  1. 1 Neonatal Medicine, Chelsea and Westminster Healthcare NHS Trust, London, UK
  2. 2 Neonatal Intensive Care Unit, Princess Anne Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, UK
  3. 3 Paediatrics, University of Oxford, Oxford, UK
  4. 4 Centre for Perinatal Research, University of Nottingham School of Medicine, Nottingham, UK
  5. 5 Neonatal Unit, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK
  6. 6 Department of Pediatrics, Royal Hobart Hospital, Hobart, Tasmania, Australia
  7. 7 Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia
  8. 8 Neonatal Medicine, Imperial College London School of Public Health, London, UK
  1. Correspondence to Dr Claire A Murphy; drclaireamurphy{at}gmail.com

Abstract

Less invasive surfactant administration (LISA) is an increasingly popular technique to deliver surfactant to spontaneously breathing preterm infants with respiratory distress syndrome. The optimal method of alleviating the pain and discomfort associated with LISA, either pharmacological or non-pharmacological, while maintaining spontaneous respiration remains unclear. There is limited evidence to guide clinicians, resulting in wide variations in practice. The aim of this article is to summarise the current knowledge and evidence gaps regarding the use of premedication prior to LISA.

  • Analgesia
  • Intensive Care Units, Neonatal
  • Neonatology
  • Pain
  • Pharmacology

https://doi.org/10.1136/archdischild-2024-326947

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    Footnotes

    • X @claire_anne_neo, @shaliniojha7, @DrCGale

    • Contributors CAM, KCWG, RS, SO, PAD and CG contributed to the study design. CAM drafted the manuscript and all authors revised and approved the final manuscript. CAM is the guarantor.

    • Competing interests None declared.

    • Provenance and peer review Commissioned; externally peer reviewed.