PT - JOURNAL ARTICLE AU - Perme, Tina AU - Kornhauser Cerar, Lilijana AU - Schwaberger, Bernhard AU - Urlesberger, Berndt AU - Wolfsberger, Christina Helene AU - Baik, Nariae AU - Goeral, Katharina AU - Hammerl, Marlene AU - Dempsey, Eugene M AU - Springer, Laila AU - Lista, Gianluca AU - Szczapa, Tomasz AU - Fuchs, Hans AU - Karpinski, Lukasz AU - Bua, Jenny AU - Avian, Alexander AU - Law, Brenda Hiu Yan AU - Buchmayer, Julia AU - Kiechl-Kohlendorfer, Ursula AU - Schwarz, Christoph E AU - Gruendler, Kerstin AU - Stucchi, Ilaria AU - Klebermass-Schrehof, Katrin AU - Schmölzer, Georg M AU - Pichler, Gerhard ED - TI - Effect of timing of umbilical cord clamping on cerebral regional tissue oxygenation: a secondary analysis of the COSGOD III trial AID - 10.1136/archdischild-2024-327946 DP - 2025 Apr 29 TA - Archives of Disease in Childhood - Fetal and Neonatal Edition PG - fetalneonatal-2024-327946 4099 - http://fn.bmj.com/content/early/2025/04/29/archdischild-2024-327946.short 4100 - http://fn.bmj.com/content/early/2025/04/29/archdischild-2024-327946.full AB - Aim To determine how different cord clamping strategies affect cerebral oxygenation in the first 15 min after birth in preterm infants.Methods A post-hoc secondary outcome analysis of a multicentre prospective randomised clinical trial (COSGOD III) conducted between October 2017 and October 2021 in 11 tertiary neonatal intensive care units in six countries in Europe and in Canada. In the present ancillary study, all included premature neonates (<32 weeks gestation) were retrospectively assigned to three groups according to the timing of cord clamping (G1<30 s, G2 30–60 s, G3>30 s). The aim of this study was to evaluate differences in cerebral regional oxygen saturation (crSO2) and cerebral fractional tissue oxygen extraction (cFTOE) within the first 15 min after birth in preterm neonates based on the timing of cord clamping.Results 572 infants (n=339 (G1), n=164 (G2) and n=69 (G3)) were included in the final ancillary analysis. There were no statistically significant differences in crSO2 and cFTOE between the three groups. There were no statistically significant differences between the three groups in neonatal morbidities, particularly importantly in the degree of cerebral injury, as measured by any degree of intraventricular haemorrhage or cystic periventricular leukomalacia.Conclusions No significant differences in crSO2 and cFTOE during the first 15 min after birth were observed; however, some effect may have been modified by protocol-guided titration of supplemental oxygen in the intervention arm. Thus, in our study, we did not find a correlation between deferred cord clamping and improved cerebral oxygenation immediately after birth.Trial registration number NCT03166722.All data relevant to the study are included in the article or uploaded as supplementary information.